Novel Highly Efficient Antibacterial Chitosan-Based Films

In this study, we elaborated new chitosan-based films reinforced by iron(III)-containing chitosan nanoparticles Fe(III)-CS-NPs at different concentrations. We found that the optimum concentration of for improvement antibacterial and mechanical properties was 10% (σb = ca. 8.8 N/mm2, εb 41%, inhibition zone S. aureus 16.8 mm E. coli 11.2 mm). Also, using click-chemistry approach (thiol–ene reaction), have synthesized a novel water-soluble cationic derivative chitin. The addition chitin to polymer matrix film significantly improved its 11.6 75%) antimicrobial (inhibition 19.6 14.2 mm) properties. key mechanism action obtained is disruption membranes bacterial cells. are interest potential biomedical food applications.